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KMID : 1123920050190030792
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 3 p.792 ~ p.796
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Synthesis and Biological Activity of Geranyloxy Compounds
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Oh Hyun-Ju
Oh In-Kio
Na Young-Soon
Kim Myung-Ju
Baek Seung-Hwa
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Abstract
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Disk assays on the compounds (10 and 12) showed both to have antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (1 and 3 mm inhibition zones at ), but not against the Gram-positive bacterium B. subtilis or the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa or fungi Cladosporium resinae and Candida albicans. However, the compound (13) did not show against antifungal activity. The geranyloxy compounds (10, 12, and 13) were cytotoxic to P388 murine leukaemia cells ATCC CCL 46 P388D1, ( >6,250 ng/mL at ). These results suggest that The geranyloxy compounds possesses antimicrobial and antitumor activities.
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KEYWORD
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Trichophyton mentagrophytes, Antifungal activity
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